

| Numéro de catalogue | HX938022 |
|---|---|
| Description |
Recombinant Human EWSR1 Protein, N-GST & C-His (HX938022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Système d'expression | E. coli |
| Numéro d'accès | Q01844 |
| Longueur de protéine | Asp353-Arg446 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Espèces | Homo sapiens (Human) |
| Nature | Recombinant |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Pureté | >90% as determined by SDS-PAGE. |
| Forme | Lyophilized |
| Tampon de stockage | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Noms alternatifs | EWS, EWS oncogene, EWSR1, Ewing sarcoma breakpoint region 1 protein, RNA-binding protein EWS |
| Contexte | RNA-binding protein EWS is a ~68 kDa protein. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. 1. Nguyen, CD. et al. (2011) Journal of molecular biology 407, 273-83. PMID: 21256132 2. Li, KK. et al. (2000) The Journal of biological chemistry 275, 23053-8. PMID: 10767297 |
| Note | For research use only |
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