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| カタログ番号 | HD398012 |
|---|---|
| 説明 |
Recombinant Human FBXL3 Protein, N-His (HD398012) expressed in E. coli, spanning Gly37-Trp428. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9UKT7 |
| タンパク質長 | Gly37-Trp428 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 46.89 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | F-box and leucine-rich repeat protein 3A, F-box/LRR-repeat protein 3, F-box/LRR-repeat protein 3A, FBL3A, FBXL3, FBXL3A |
| 背景 | F-box/LRR-repeat protein 3 is a ~48 kDa protein. Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. 1. Busino, L. et al. (2007) Science (New York, N.Y.) 316, 900-4. PMID: 17463251 2. Yoo, SH. et al. (2013) Cell 152, 1091-105. PMID: 23452855 3. Scott, DC. et al. (2016) Cell 166, 1198-1214.e24. PMID: 27565346 |
| 注意事項 | For research use only |
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