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Anti-Human FBXL3 Polyclonal Antibody (HD398014)

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Overview
Catalog No.HD398014
Description
Anti-Human FBXL3 Polyclonal Antibody (HD398014) is a rabbit polyclonal antibody detecting FBXL3. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human FBXL3 (Gly37-Trp428).
Target F-box and leucine-rich repeat protein 3A, F-box/LRR-repeat protein 3, F-box/LRR-repeat protein 3A, FBL3A, FBXL3, FBXL3A
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9UKT7
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

F-box/LRR-repeat protein 3 (FBXL3) is a ~48 kDa protein. Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.

1. Busino, L. et al. (2007) Science (New York, N.Y.) 316, 900-4. PMID: 17463251
2. Yoo, SH. et al. (2013) Cell 152, 1091-105. PMID: 23452855
3. Scott, DC. et al. (2016) Cell 166, 1198-1214.e24. PMID: 27565346
Note For research use only
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Datasheet
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Formula
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Anti-Human FBXL3 Polyclonal Antibody

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