Human FBXL3 Recombinant Protein (N-His) (HD398012)

Name: Human FBXL3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD398012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD398012
Description	Recombinant Human FBXL3 Protein, N-His (HD398012) expressed in E. coli, spanning Gly37-Trp428. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9UKT7
Protein length	Gly37-Trp428
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	46.89 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	F-box and leucine-rich repeat protein 3A, F-box/LRR-repeat protein 3, F-box/LRR-repeat protein 3A, FBL3A, FBXL3, FBXL3A
Background	F-box/LRR-repeat protein 3 is a ~48 kDa protein. Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. 1. Busino, L. et al. (2007) Science (New York, N.Y.) 316, 900-4. PMID: 17463251 2. Yoo, SH. et al. (2013) Cell 152, 1091-105. PMID: 23452855 3. Scott, DC. et al. (2016) Cell 166, 1198-1214.e24. PMID: 27565346
Note	For research use only

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Datasheet

Human FBXL3 Recombinant Protein (N-His).pdf

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Human FBXL3 Recombinant Protein (N-His) (HD398012)

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