Human GEN1 Recombinant Protein (N-His) (HD546012)

Name: Human GEN1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD546012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Обзор

Каталожный номер	HD546012
Описание	Recombinant Human GEN1 Protein, N-His (HD546012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	Q17RS7
Длина белка	Met1-Pro473
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	EC:3.1.-.-, Flap endonuclease GEN homolog 1, GEN1
Фон	Flap endonuclease GEN homolog 1 is a ~102 kDa protein. Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction. 1. Ip, SC. et al. (2008) Nature 456, 357-61. PMID: 19020614 2. Lee, SH. et al. (2015) eLife 4. PMID: 26682650 3. Chan, YW. et al. (2015) Nucleic acids research 43, 10882-92. PMID: 26578604 4. Shah Punatar, R. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 443-450. PMID: 28049850
Примечание	For research use only

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Ссылки

Даташит

Human GEN1 Recombinant Protein (N-His).pdf

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Formula

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C₁ (Stock Conc.)

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Working Solution

C₂ (Working Conc.)

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