Human GluN2D/NR2D Recombinant Protein (N-His) (HT027012)

Name: Human GluN2D/NR2D Recombinant Protein (N-His)
Brand: abinScience
SKU: HT027012
Price: 211 USD
Availability: InStock

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Número de catálogo	HT027012
Descripción	Recombinant Human GluN2D/NR2D Protein, N-His (HT027012) expressed in E. coli, spanning Arg49-Tyr413. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	O15399
Longitud de proteína	Arg49-Tyr413
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	41.37 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	EB11, GRIN2D, GluN2D, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate receptor ionotropic, NMDA 2D, N-methyl D-aspartate receptor subtype 2D, NMDAR2D, NR2D
Fondo	Glutamate receptor ionotropic, NMDA 2D is a ~143 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. 1. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626 2. Li, D. et al. (2016) American journal of human genetics 99, 802-816. PMID: 27616483 3. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851 4. Hess, SD. et al. (1998) Journal of neurochemistry 70, 1269-79. PMID: 9489750 5. Ogden, KK. et al. (2017) PLoS genetics 13, e1006536. PMID: 28095420
Nota	For research use only

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Datasheet

Human GluN2D/NR2D Recombinant Protein (N-His).pdf

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