Human GluN2D/NR2D Recombinant Protein (N-His) (HT027012)

Name: Human GluN2D/NR2D Recombinant Protein (N-His)
Brand: abinScience
SKU: HT027012
Price: 211 USD
Availability: InStock

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1mg

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Каталожный номер	HT027012
Описание	Recombinant Human GluN2D/NR2D Protein, N-His (HT027012) expressed in E. coli, spanning Arg49-Tyr413. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	O15399
Длина белка	Arg49-Tyr413
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	41.37 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	EB11, GRIN2D, GluN2D, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate receptor ionotropic, NMDA 2D, N-methyl D-aspartate receptor subtype 2D, NMDAR2D, NR2D
Фон	Glutamate receptor ionotropic, NMDA 2D is a ~143 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. 1. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626 2. Li, D. et al. (2016) American journal of human genetics 99, 802-816. PMID: 27616483 3. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851 4. Hess, SD. et al. (1998) Journal of neurochemistry 70, 1269-79. PMID: 9489750 5. Ogden, KK. et al. (2017) PLoS genetics 13, e1006536. PMID: 28095420
Примечание	For research use only

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Human GluN2D/NR2D Recombinant Protein (N-His).pdf

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