Human HDAC6 Recombinant Protein (N-His) (HV287012)

Name: Human HDAC6 Recombinant Protein (N-His)
Brand: abinScience
SKU: HV287012
Price: 211 USD
Availability: InStock

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Vista general

Número de catálogo	HV287012
Descripción	Recombinant Human HDAC6 Protein, N-His (HV287012) expressed in E. coli, spanning Ser479-Arg835. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q9UBN7
Longitud de proteína	Ser479-Arg835
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	41.23 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	KIAA0901, Histone deacetylase 6, HDAC6, HD6, Tubulin-lysine deacetylase HDAC6
Fondo	Protein deacetylase HDAC6 is a ~131 kDa protein. Deacetylates a wide range of non-histone substrates. Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Required for cilia disassembly via deacetylation of alpha-tubulin. Alpha-tubulin deacetylation results in destabilization of dynamic microtubules. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. 1. Hubbert, C. et al. (2002) Nature 417, 455-8. PMID: 12024216 2. Parmigiani, RB. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 9633-8. PMID: 18606987 3. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065 4. Zhang, M. et al. (2014) Molecular cell 55, 31-46. PMID: 24882211 5. Ran, J. et al. (2015) Scientific reports 5, 12917. PMID: 26246421 6. Wang, R. et al. (2019) The Journal of cell biology 218, 267-284. PMID: 30538141 7. You, Z. et al. (2019) Nature communications 10, 5792. PMID: 31857589 8. Zhang, M. et al. (2019) The Journal of biological chemistry 294, 5813-5826. PMID: 30770470 9. Sun, C. et al. (2024) Cells 13. PMID: 38534334 10. Jin, J. et al. (2025) Nature 637, 215-223. PMID: 39567688
Nota	For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Human HDAC6 Recombinant Protein (N-His)

Referencias

Datasheet

Human HDAC6 Recombinant Protein (N-His).pdf

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Formula

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