Anti-HDAC6 Polyclonal Antibody (HV287014)

Name: Anti-HDAC6 Polyclonal Antibody
Brand: abinScience
SKU: HV287014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HV287014

Description

Anti-HDAC6 Polyclonal Antibody (HV287014) is a rabbit polyclonal antibody detecting HDAC6 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human HDAC6 (Ser479-Arg835).

Target

KIAA0901, Histone deacetylase 6, HDAC6, HD6, Tubulin-lysine deacetylase HDAC6

Purification

Purified by antigen affinity column.

Accession

Q9UBN7

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Protein deacetylase HDAC6 is a ~131 kDa protein. Deacetylates a wide range of non-histone substrates. Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Required for cilia disassembly via deacetylation of alpha-tubulin. Alpha-tubulin deacetylation results in destabilization of dynamic microtubules. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy.

1. Hubbert, C. et al. (2002) Nature 417, 455-8. PMID: 12024216

2. Parmigiani, RB. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 9633-8. PMID: 18606987

3. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065

4. Zhang, M. et al. (2014) Molecular cell 55, 31-46. PMID: 24882211

5. Ran, J. et al. (2015) Scientific reports 5, 12917. PMID: 26246421

6. Wang, R. et al. (2019) The Journal of cell biology 218, 267-284. PMID: 30538141

7. You, Z. et al. (2019) Nature communications 10, 5792. PMID: 31857589

8. Zhang, M. et al. (2019) The Journal of biological chemistry 294, 5813-5826. PMID: 30770470

9. Sun, C. et al. (2024) Cells 13. PMID: 38534334

10. Jin, J. et al. (2025) Nature 637, 215-223. PMID: 39567688

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-HDAC6 polyclonal antibody at 1ug/mL on recombinant HDAC6 (Catalog No. HV287012).

References

Datasheet

Anti-HDAC6 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-HDAC6 Polyclonal Antibody (HV287014)

Overview

Images

References

Datasheet

SDS

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