Human IRF1 Recombinant Protein (N-His) (HY164042)

Name: Human IRF1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HY164042
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HY164042
説明	Recombinant Human IRF1 Protein, N-His (HY164042) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
発現システム	E. coli
アクセッション番号	P10914
タンパク質長	Met1-Pro114
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	15.63 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	IRF-1, IRF1, Interferon regulatory factor 1
背景	Interferon regulatory factor 1 is a ~36 kDa protein. Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Has an essentail role in IFNG-dependent immunity to mycobacteria. Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters. 1. Oshima, S. et al. (2004) Molecular and cellular biology 24, 6298-310. PMID: 15226432 2. Dornan, D. et al. (2004) Molecular and cellular biology 24, 10083-98. PMID: 15509808 3. Su, ZZ. et al. (2007) Journal of cellular physiology 213, 502-10. PMID: 17516545 4. Park, J. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 17028-33. PMID: 17942705 5. Bowie, ML. et al. (2008) Advances in experimental medicine and biology 617, 367-74. PMID: 18497060 6. Huang, Y. et al. (2009) PloS one 4, e5397. PMID: 19404407 7. Gao, J. et al. (2010) Cell death and differentiation 17, 699-709. PMID: 19851330 8. Qi, H. et al. (2012) The Journal of biological chemistry 287, 12622-33. PMID: 22367195 9. Somerville, TDD. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 11471-11482. PMID: 32385160 10. Tanaka, N. et al. (1993) Molecular and cellular biology 13, 4531-8. PMID: 7687740
注意事項	For research use only