Human IRS2 Recombinant Protein (N-His) (HV817042)

Name: Human IRS2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HV817042
Price: 211 USD
Availability: InStock

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Número de catálogo	HV817042
Descripción	Recombinant Human IRS2 Protein, N-His (HV817042) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q9Y4H2
Longitud de proteína	Ser30-Asp152
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	IRS-2, IRS2, Insulin receptor substrate 2
Fondo	Insulin receptor substrate 2 is a ~137 kDa protein. Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R. Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism. Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2. Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade. Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. 1. Fukushima, T. et al. (2015) Nature communications 6, 6780. PMID: 25879670 2. Geng, Y. et al. (2014) The Journal of biological chemistry 289, 11230-11241. PMID: 24616100 3. Duan, C. et al. (2004) The Journal of biological chemistry 279, 43684-91. PMID: 15316008 4. Heller, NM. et al. (2008) Science signaling 1, ra17. PMID: 19109239 5. Manohar, S. et al. (2020) Molecular & cellular proteomics : MCP 19, 1450-1467. PMID: 32554797
Nota	For research use only

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Datasheet

Human IRS2 Recombinant Protein (N-His).pdf

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