Human KCNH2/ERG1 Recombinant Protein (N-His) (HC535022)

Name: Human KCNH2/ERG1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC535022
Price: 211 USD
Availability: InStock

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1mg

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HC535022
説明	Recombinant Human KCNH2/ERG1 Protein, N-His (HC535022) expressed in E. coli, spanning Pro10-Lys135. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	E. coli
アクセッション番号	Q12809
タンパク質長	Pro10-Lys135
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	16.57 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	ERG, ERG-1, ERG1, Eag homolog, Eag-related protein 1, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, H-ERG, HERG, KCNH2, Potassium voltage-gated channel subfamily H member 2, Voltage-gated inwardly rectifying potassium channel KCNH2, Voltage-gated potassium channel subunit Kv11.1, hERG-1, hERG1
背景	Voltage-gated inwardly rectifying potassium channel KCNH2 is a ~126 kDa protein. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity. 1. Abbott, GW. et al. (1999) Cell 97, 175-87. PMID: 10219239 2. Kagan, A. et al. (2000) The Journal of biological chemistry 275, 11241-8. PMID: 10753933 3. Paulussen, A. et al. (2000) Human mutation 15, 483. PMID: 10790218 4. Cui, J. et al. (2000) Current biology : CB 10, 671-4. PMID: 10837251 5. Yang, P. et al. (2002) Circulation 105, 1943-8. PMID: 11997281 6. Gong, Q. et al. (2002) American journal of physiology. Heart and circulatory physiology 283, H77-84. PMID: 12063277 7. Guasti, L. et al. (2008) Molecular and cellular biology 28, 5043-60. PMID: 18559421 8. Aidery, P. et al. (2012) Biochemical and biophysical research communications 418, 830-5. PMID: 22314138 9. Ng, CA. et al. (2012) PloS one 7, e31640. PMID: 22359612 10. Kang, Y. et al. (2015) The Biochemical journal 472, 71-82. PMID: 26363003
注意事項	For research use only