

| Каталожный номер | HC535022 |
|---|---|
| Описание |
Recombinant Human KCNH2/ERG1 Protein, N-His (HC535022) expressed in E. coli, spanning Pro10-Lys135. Purity: >90% by SDS-PAGE.
Highlights
|
| Система экспрессии | E. coli |
| Номер доступа | Q12809 |
| Длина белка | Pro10-Lys135 |
| Применения | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Виды | Homo sapiens (Human) |
| Характер | Recombinant |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Чистота | >90% as determined by SDS-PAGE. |
| Прогнозируемая молекулярная масса | 16.57 kDa |
| Форма | Lyophilized |
| Буфер хранения | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Реконституция | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Доставка | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Альтернативные названия | ERG, ERG-1, ERG1, Eag homolog, Eag-related protein 1, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, H-ERG, HERG, KCNH2, Potassium voltage-gated channel subfamily H member 2, Voltage-gated inwardly rectifying potassium channel KCNH2, Voltage-gated potassium channel subunit Kv11.1, hERG-1, hERG1 |
| Фон | Voltage-gated inwardly rectifying potassium channel KCNH2 is a ~126 kDa protein. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity. 1. Abbott, GW. et al. (1999) Cell 97, 175-87. PMID: 10219239 2. Kagan, A. et al. (2000) The Journal of biological chemistry 275, 11241-8. PMID: 10753933 3. Paulussen, A. et al. (2000) Human mutation 15, 483. PMID: 10790218 4. Cui, J. et al. (2000) Current biology : CB 10, 671-4. PMID: 10837251 5. Yang, P. et al. (2002) Circulation 105, 1943-8. PMID: 11997281 6. Gong, Q. et al. (2002) American journal of physiology. Heart and circulatory physiology 283, H77-84. PMID: 12063277 7. Guasti, L. et al. (2008) Molecular and cellular biology 28, 5043-60. PMID: 18559421 8. Aidery, P. et al. (2012) Biochemical and biophysical research communications 418, 830-5. PMID: 22314138 9. Ng, CA. et al. (2012) PloS one 7, e31640. PMID: 22359612 10. Kang, Y. et al. (2015) The Biochemical journal 472, 71-82. PMID: 26363003 |
| Примечание | For research use only |



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