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| カタログ番号 | HD579012 |
|---|---|
| 説明 |
Recombinant Human KDM1A Protein, N-His (HD579012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O60341 |
| タンパク質長 | Arg524-Met852 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | AOF2, BHC110, BRAF35-HDAC complex protein BHC110, EC:1.14.11.-, EC:1.14.11.65, EC:1.14.99.66, Flavin-containing amine oxidase domain-containing protein 2, KDM1, KDM1A, KIAA0601, LSD1, Lysine-specific histone demethylase 1A, [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A |
| 背景 | Lysine-specific histone demethylase 1A is a ~92 kDa protein. Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2). May play a role in the repression of neuronal genes. 1. Shi, Y. et al. (2004) Cell 119, 941-53. PMID: 15620353 2. Forneris, F. et al. (2005) FEBS letters 579, 2203-7. PMID: 15811342 3. Lee, MG. et al. (2005) Nature 437, 432-5. PMID: 16079794 4. Metzger, E. et al. (2005) Nature 437, 436-9. PMID: 16079795 5. Shi, YJ. et al. (2005) Molecular cell 19, 857-64. PMID: 16140033 6. Forneris, F. et al. (2005) The Journal of biological chemistry 280, 41360-5. PMID: 16223729 7. Luo, H. et al. (2016) Cell reports 15, 2665-78. PMID: 27292636 10. Lin, Y. et al. (2010) The EMBO journal 29, 1803-16. PMID: 20389281 |
| 注意事項 | For research use only |
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