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| カタログ番号 | HC198012 |
|---|---|
| 説明 |
Recombinant Human LRPPRC Protein, N-His (HC198012) expressed in E. coli, spanning Thr385-Asp725. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P42704 |
| タンパク質長 | Thr385-Asp725 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 41.31 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 130 kDa leucine-rich protein, GP130, LRP 130, LRP130, LRPPRC, Leucine-rich PPR motif-containing protein, mitochondrial |
| 背景 | Leucine-rich PPR motif-containing protein, mitochondrial is a ~157 kDa protein. May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex. Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm. May bind mature mRNA in the nucleus outer membrane. 1. Topisirovic, I. et al. (2009) The EMBO journal 28, 1087-98. PMID: 19262567 2. Volpon, L. et al. (2017) RNA (New York, N.Y.) 23, 927-937. PMID: 28325843 3. Zou, J. et al. (2013) The Biochemical journal 454, 447-57. PMID: 23822101 |
| 注意事項 | For research use only |
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