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Anti-Human LRPPRC Polyclonal Antibody (HC198014)

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Anti-Human LRPPRC Polyclonal Antibody
Anti-Human LRPPRC Polyclonal Antibody
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Overview
Catalog No.HC198014
Description
Anti-Human LRPPRC Polyclonal Antibody (HC198014) is a rabbit polyclonal antibody detecting LRPPRC. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human LRPPRC (Thr385-Asp725).
Target 130 kDa leucine-rich protein, GP130, LRP 130, LRP130, LRPPRC, Leucine-rich PPR motif-containing protein, mitochondrial
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P42704
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) is a ~157 kDa protein. May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex. Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm. May bind mature mRNA in the nucleus outer membrane.

1. Topisirovic, I. et al. (2009) The EMBO journal 28, 1087-98. PMID: 19262567
2. Volpon, L. et al. (2017) RNA (New York, N.Y.) 23, 927-937. PMID: 28325843
3. Zou, J. et al. (2013) The Biochemical journal 454, 447-57. PMID: 23822101
Note For research use only
Images
  • Anti-Human LRPPRC Polyclonal Antibody

    Western blot

    Western blot analysis was performed using anti-LRPPRC polyclonal antibody at 1ug/mL on various samples.
    Lane 1: HepG2 cell lysate
    Lane 2: SH-SY5Y cell lysate

References
Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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