Human LRRC8E Recombinant Protein (N-His) (HD329012)

Name: Human LRRC8E Recombinant Protein (N-His)
Brand: abinScience
SKU: HD329012
Price: 211 USD
Availability: InStock

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Número de catálogo	HD329012
Descripción	Recombinant Human LRRC8E Protein, N-His (HD329012) expressed in E. coli, spanning Leu411-Glu796. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q6NSJ5
Longitud de proteína	Leu411-Glu796
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	45.56 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	LRRC8E, Leucine-rich repeat-containing protein 8E, Volume-regulated anion channel subunit LRRC8E
Fondo	Volume-regulated anion channel subunit LRRC8E is a ~90 kDa protein. Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. 1. Voss, FK. et al. (2014) Science (New York, N.Y.) 344, 634-8. PMID: 24790029 2. Syeda, R. et al. (2016) Cell 164, 499-511. PMID: 26824658 3. Lutter, D. et al. (2017) Journal of cell science 130, 1122-1133. PMID: 28193731 4. Lahey, LJ. et al. (2020) Molecular cell 80, 578-591.e5. PMID: 33171122
Nota	For research use only

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Datasheet

Human LRRC8E Recombinant Protein (N-His).pdf

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