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Anti-Human LRRC8E Polyclonal Antibody (HD329014)

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Overview
Catalog No.HD329014
Description
Anti-Human LRRC8E Polyclonal Antibody (HD329014) is a rabbit polyclonal antibody detecting LRRC8E. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human LRRC8E (Leu411-Glu796).
Target LRRC8E, Leucine-rich repeat-containing protein 8E, Volume-regulated anion channel subunit LRRC8E
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q6NSJ5
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Volume-regulated anion channel subunit LRRC8E is a ~90 kDa protein. Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.

1. Voss, FK. et al. (2014) Science (New York, N.Y.) 344, 634-8. PMID: 24790029
2. Syeda, R. et al. (2016) Cell 164, 499-511. PMID: 26824658
3. Lutter, D. et al. (2017) Journal of cell science 130, 1122-1133. PMID: 28193731
4. Lahey, LJ. et al. (2020) Molecular cell 80, 578-591.e5. PMID: 33171122
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human LRRC8E Polyclonal Antibody

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