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| カタログ番号 | HC410012 |
|---|---|
| 説明 |
Recombinant Human LTBP1 Protein, N-His (HC410012) expressed in E. coli, spanning Glu876-Asp1315. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q14766 |
| タンパク質長 | Glu876-Asp1315 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 50.40 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | LTBP-1, LTBP1, Latent-transforming growth factor beta-binding protein 1, TGF-beta1-BP-1, Transforming growth factor beta-1-binding protein 1 |
| 背景 | Latent-transforming growth factor beta-binding protein 1 is a ~186 kDa protein. Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. 1. Miyazono, K. et al. (1991) The EMBO journal 10, 1091-101. PMID: 2022183 2. Saharinen, J. et al. (1996) The EMBO journal 15, 245-53. PMID: 8617200 3. Gleizes, PE. et al. (1996) The Journal of biological chemistry 271, 29891-6. PMID: 8939931 4. Annes, JP. et al. (2004) The Journal of cell biology 165, 723-34. PMID: 15184403 5. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742 |
| 注意事項 | For research use only |
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