

| Número de catálogo | HW326022 |
|---|---|
| Descripción |
Recombinant Human MATR3 Protein, N-GST & C-His (HW326022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Sistema de expresión | E. coli |
| Número de acceso | P43243 |
| Longitud de proteína | Lys478-Val576 |
| Aplicaciones | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Especies | Homo sapiens (Human) |
| Naturaleza | Recombinant |
| Nivel de endotoxinas | Please contact with the lab for this information. |
| Pureza | >90% as determined by SDS-PAGE. |
| Forma | Lyophilized |
| Buffer de almacenamiento | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
| Reconstitución | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Envío | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Nombres alternativos | KIAA0723, MATR3, Matrin-3 |
| Fondo | Matrin-3 is a ~94 kDa protein. May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins. 1. Morchikh, M. et al. (2017) Molecular cell 67, 387-399.e5. PMID: 28712728 2. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947 3. Treiber, T. et al. (2017) Molecular cell 66, 270-284.e13. PMID: 28431233 |
| Nota | For research use only |
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