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| カタログ番号 | HB871012 |
|---|---|
| 説明 |
Recombinant Human MC4R Protein, N-His (HB871012) expressed in E. coli. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P32245 |
| タンパク質長 | Met1-Gln43&Phe216-Thr248&Arg305-Tyr332 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 14.07 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | MC4-R, MC4R, Melanocortin receptor 4 |
| 背景 | Melanocortin receptor 4 is a ~36 kDa protein. G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which promotes anorexogenic signaling in the hypothalamus and contributes to a negative energy balance. Regulates food intake: activation by agonists suppresses appetite, whereas the antagonist Agouti-related protein/AGRP precludes agonist-induced signaling, thereby stimulating appetite. Modulates the firing activity of neurons in paraventricular nucleus (PVN) of the hypothalamus via alpha-MSH and AGRP regulation of inwardly rectifying potassium channel KCNJ13 closure, independently of G(s) signaling. 1. Farooqi, IS. et al. (2003) The New England journal of medicine 348, 1085-95. PMID: 12646665 2. Valli-Jaakola, K. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 940-5. PMID: 14764818 3. Delhanty, PJ. et al. (2014) Molecular biology reports 41, 7967-72. PMID: 25163632 4. Yu, J. et al. (2020) Science (New York, N.Y.) 368, 428-433. PMID: 32327598 5. Israeli, H. et al. (2021) Science (New York, N.Y.) 372, 808-814. PMID: 33858992 6. Gantz, I. et al. (1993) The Journal of biological chemistry 268, 15174-9. PMID: 8392067 7. Yeo, GS. et al. (2003) Human molecular genetics 12, 561-74. PMID: 12588803 8. Ollmann, MM. et al. (1997) Science (New York, N.Y.) 278, 135-8. PMID: 9311920 |
| 注意事項 | For research use only |
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