Anti-Human MC4R Polyclonal Antibody (HB871014)

Name: Anti-Human MC4R Polyclonal Antibody
Brand: abinScience
SKU: HB871014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HB871014

Description

Anti-Human MC4R Polyclonal Antibody (HB871014) is a rabbit polyclonal antibody detecting MC4R. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MC4R (Met1-Gln43&Phe216-Thr248&Arg305-Tyr332).

Target

MC4-R, MC4R, Melanocortin receptor 4

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P32245

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Melanocortin receptor 4 (MC4R) is a ~36 kDa protein. G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which promotes anorexogenic signaling in the hypothalamus and contributes to a negative energy balance. Regulates food intake: activation by agonists suppresses appetite, whereas the antagonist Agouti-related protein/AGRP precludes agonist-induced signaling, thereby stimulating appetite. Modulates the firing activity of neurons in paraventricular nucleus (PVN) of the hypothalamus via alpha-MSH and AGRP regulation of inwardly rectifying potassium channel KCNJ13 closure, independently of G(s) signaling.

1. Farooqi, IS. et al. (2003) The New England journal of medicine 348, 1085-95. PMID: 12646665

2. Valli-Jaakola, K. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 940-5. PMID: 14764818

3. Delhanty, PJ. et al. (2014) Molecular biology reports 41, 7967-72. PMID: 25163632

4. Yu, J. et al. (2020) Science (New York, N.Y.) 368, 428-433. PMID: 32327598

5. Israeli, H. et al. (2021) Science (New York, N.Y.) 372, 808-814. PMID: 33858992

6. Gantz, I. et al. (1993) The Journal of biological chemistry 268, 15174-9. PMID: 8392067

7. Yeo, GS. et al. (2003) Human molecular genetics 12, 561-74. PMID: 12588803

8. Ollmann, MM. et al. (1997) Science (New York, N.Y.) 278, 135-8. PMID: 9311920

Note

For research use only

Images

References

Datasheet

Anti-Human MC4R Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human MC4R Polyclonal Antibody (HB871014)

Overview

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References

Datasheet

SDS

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