Human MORC3 Recombinant Protein (N-His) (HD500012)

Name: Human MORC3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD500012
Price: 211 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HD500012
Description	Recombinant Human MORC3 Protein, N-His (HD500012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q14149
Longueur de protéine	Met1-Glu455
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	KIAA0136, MORC family CW-type zinc finger protein 3, MORC3, NXP2, Nuclear matrix protein 2, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3
Contexte	MORC family CW-type zinc finger protein 3 is a ~107 kDa protein. Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. 1. Sloan, E. et al. (2016) Journal of virology 90, 8621-33. PMID: 27440897 2. Gaidt, MM. et al. (2021) Nature 600, 138-142. PMID: 34759314 3. Takahashi, K. et al. (2007) Molecular biology of the cell 18, 1701-9. PMID: 17332504 4. Mimura, Y. et al. (2010) Journal of cell science 123, 2014-24. PMID: 20501696 5. Kimura, Y. et al. (2002) The Journal of biological chemistry 277, 20611-7. PMID: 11927593 6. Liu, Y. et al. (2016) The Journal of biological chemistry 291, 9000-13. PMID: 26933034
Note	For research use only

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SDS-PAGE

SDS-PAGE for Human MORC3 Recombinant Protein (N-His)

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Human MORC3 Recombinant Protein (N-His).pdf

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Formula

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