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Anti-Human MORC3 Polyclonal Antibody (HD500014)

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Overview
Catalog No.HD500014
Description
Anti-Human MORC3 Polyclonal Antibody (HD500014) is a rabbit polyclonal antibody detecting MORC3. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human MORC3 (Met1-Glu455).
Target KIAA0136, MORC family CW-type zinc finger protein 3, MORC3, NXP2, Nuclear matrix protein 2, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q14149
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

MORC family CW-type zinc finger protein 3 (MORC3) is a ~107 kDa protein. Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3.

1. Sloan, E. et al. (2016) Journal of virology 90, 8621-33. PMID: 27440897
2. Gaidt, MM. et al. (2021) Nature 600, 138-142. PMID: 34759314
3. Takahashi, K. et al. (2007) Molecular biology of the cell 18, 1701-9. PMID: 17332504
4. Mimura, Y. et al. (2010) Journal of cell science 123, 2014-24. PMID: 20501696
5. Kimura, Y. et al. (2002) The Journal of biological chemistry 277, 20611-7. PMID: 11927593
6. Liu, Y. et al. (2016) The Journal of biological chemistry 291, 9000-13. PMID: 26933034
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human MORC3 Polyclonal Antibody

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