中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HD500012 |
|---|---|
| 説明 |
Recombinant Human MORC3 Protein, N-His (HD500012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q14149 |
| タンパク質長 | Met1-Glu455 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | KIAA0136, MORC family CW-type zinc finger protein 3, MORC3, NXP2, Nuclear matrix protein 2, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3 |
| 背景 | MORC family CW-type zinc finger protein 3 is a ~107 kDa protein. Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. 1. Sloan, E. et al. (2016) Journal of virology 90, 8621-33. PMID: 27440897 2. Gaidt, MM. et al. (2021) Nature 600, 138-142. PMID: 34759314 3. Takahashi, K. et al. (2007) Molecular biology of the cell 18, 1701-9. PMID: 17332504 4. Mimura, Y. et al. (2010) Journal of cell science 123, 2014-24. PMID: 20501696 5. Kimura, Y. et al. (2002) The Journal of biological chemistry 277, 20611-7. PMID: 11927593 6. Liu, Y. et al. (2016) The Journal of biological chemistry 291, 9000-13. PMID: 26933034 |
| 注意事項 | For research use only |
SDS-PAGE for Human MORC3 Recombinant Protein (N-His)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
