Human MTF2 Recombinant Protein (N-His) (HP178012)

Name: Human MTF2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HP178012
Price: 211 USD
Availability: InStock

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1mg

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Каталожный номер	HP178012
Описание	Recombinant Human MTF2 Protein, N-His (HP178012) expressed in E. coli, spanning Lys45-Lys335. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	Q9Y483
Длина белка	Lys45-Lys335
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	35.79 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	MTF2, Metal regulatory transcription factor 2, Metal-response element DNA-binding protein M96, Metal-response element-binding transcription factor 2, PCL2, Polycomb-like protein 2, hPCl2
Фон	Metal-response element-binding transcription factor 2 is a ~67 kDa protein. Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. 1. Musselman, CA. et al. (2012) Nature structural & molecular biology 19, 1266-72. PMID: 23142980 2. Qin, S. et al. (2013) Biochemical and biophysical research communications 430, 547-53. PMID: 23228662 3. Chen, S. et al. (2020) Molecular cell 77, 1265-1278.e7. PMID: 31959557
Примечание	For research use only

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Даташит

Human MTF2 Recombinant Protein (N-His).pdf

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