Anti-Human MTF2 IP Recombinant Antibody (SAA0253) (HP178013)

Name: Anti-Human MTF2 IP Recombinant Antibody (SAA0253)
Brand: abinScience
SKU: HP178013
Price: 191 USD
Availability: InStock

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100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP178013

Species reactivity

Human

Applications

ELISA, IF, IP

Host species

Mouse

Isotype

IgG2a

Clone ID

SAA0253

Clonality

Monoclonal

Target

hPCl2, Metal-response element-binding transcription factor 2, Polycomb-like protein 2, PCL2, MTF2, Metal regulatory transcription factor 2, Metal-response element DNA-binding protein M96

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9Y483

RRID

Anti-Human MTF2 IP Antibody (SAA0253) (abinScience Cat# HP178013, RRID:AB_3729787)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Metal-response element-binding transcription factor 2 (MTF2) is a ~67 kDa protein. Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally.

1. Musselman, CA. et al. (2012) Nature structural & molecular biology 19, 1266-72. PMID: 23142980

2. Qin, S. et al. (2013) Biochemical and biophysical research communications 430, 547-53. PMID: 23228662

3. Chen, S. et al. (2020) Molecular cell 77, 1265-1278.e7. PMID: 31959557

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human MTF2 IP Antibody (SAA0253)

References

Datasheet

Anti-Human MTF2 IP Recombinant Antibody (SAA0253).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human MTF2 IP Recombinant Antibody (SAA0253) (HP178013)

Overview

Images

References

Datasheet

SDS

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