Human MTF2 Recombinant Protein (N-His) (HP178012)

Name: Human MTF2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HP178012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HP178012
Description	Recombinant Human MTF2 Protein, N-His (HP178012) expressed in E. coli, spanning Lys45-Lys335. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9Y483
Protein length	Lys45-Lys335
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	35.79 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MTF2, Metal regulatory transcription factor 2, Metal-response element DNA-binding protein M96, Metal-response element-binding transcription factor 2, PCL2, Polycomb-like protein 2, hPCl2
Background	Metal-response element-binding transcription factor 2 is a ~67 kDa protein. Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. 1. Musselman, CA. et al. (2012) Nature structural & molecular biology 19, 1266-72. PMID: 23142980 2. Qin, S. et al. (2013) Biochemical and biophysical research communications 430, 547-53. PMID: 23228662 3. Chen, S. et al. (2020) Molecular cell 77, 1265-1278.e7. PMID: 31959557
Note	For research use only

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Datasheet

Human MTF2 Recombinant Protein (N-His).pdf

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Human MTF2 Recombinant Protein (N-His) (HP178012)

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