

| Numéro de catalogue | HW502022 |
|---|---|
| Description |
Recombinant Human NKX2-5 Protein, N-GST & C-His (HW502022) expressed in E. coli, spanning Asp105-Leu207. Purity: >90% by SDS-PAGE.
Highlights
|
| Système d'expression | E. coli |
| Numéro d'accès | P52952 |
| Longueur de protéine | Asp105-Leu207 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Espèces | Homo sapiens (Human) |
| Nature | Recombinant |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Pureté | >90% as determined by SDS-PAGE. |
| Masse moléculaire prédite | 40.59 kDa |
| Forme | Lyophilized |
| Tampon de stockage | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Noms alternatifs | CSX, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX2-5, NKX2.5, NKX2E |
| Contexte | Homeobox protein Nkx-2.5 is a ~34 kDa protein. Transcription factor required for the development of the heart and the spleen. During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression. 1. Koss, M. et al. (2012) Developmental cell 22, 913-26. PMID: 22560297 2. Pradhan, L. et al. (2012) Biochemistry 51, 6312-9. PMID: 22849347 3. Pradhan, L. et al. (2016) Biochemistry 55, 1702-10. PMID: 26926761 4. Samokhin, AO. et al. (2018) Science translational medicine 10. PMID: 29899023 |
| Note | For research use only |
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