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| カタログ番号 | HY450022 |
|---|---|
| 説明 |
Recombinant Human NR3C1 Protein, N-His (HY450022) expressed in E. coli, spanning Ser555-Lys777. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P04150 |
| タンパク質長 | Ser555-Lys777 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 28.68 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | GR, GRL, Glucocorticoid receptor, NR3C1, Nuclear receptor subfamily 3 group C member 1 |
| 背景 | Glucocorticoid receptor is a ~85 kDa protein. Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. 1. Vitellius, G. et al. (2016) Human mutation 37, 794-803. PMID: 27120390 2. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846 3. Fadda, A. et al. (2017) Scientific reports 7, 41598. PMID: 28139699 4. Fryer, CJ. et al. (1998) Nature 393, 88-91. PMID: 9590696 5. Cho, H. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, E1540-9. PMID: 25775514 |
| 注意事項 | For research use only |
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