Anti-Human NR3C1 Polyclonal Antibody (HY450014)

Name: Anti-Human NR3C1 Polyclonal Antibody
Brand: abinScience
SKU: HY450014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HY450014

Description

Anti-Human NR3C1 Polyclonal Antibody (HY450014) is a rabbit polyclonal antibody detecting NR3C1. Suitable for Mouse, Human, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human NR3C1 (Ser555-Lys777).

Target

GR, GRL, Glucocorticoid receptor, NR3C1, Nuclear receptor subfamily 3 group C member 1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P04150

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Glucocorticoid receptor (NR3C1) is a ~85 kDa protein. Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay.

1. Vitellius, G. et al. (2016) Human mutation 37, 794-803. PMID: 27120390

2. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846

3. Fadda, A. et al. (2017) Scientific reports 7, 41598. PMID: 28139699

4. Fryer, CJ. et al. (1998) Nature 393, 88-91. PMID: 9590696

5. Cho, H. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, E1540-9. PMID: 25775514

Note

For research use only

Images

References

Datasheet

Anti-Human NR3C1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human NR3C1 Polyclonal Antibody (HY450014)

Overview

Images

References

Datasheet

SDS

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