Human NR3C1 Recombinant Protein (N-His) (HY450022)

Name: Human NR3C1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HY450022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HY450022
Description	Recombinant Human NR3C1 Protein, N-His (HY450022) expressed in E. coli, spanning Ser555-Lys777. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P04150
Protein length	Ser555-Lys777
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	28.68 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	GR, GRL, Glucocorticoid receptor, NR3C1, Nuclear receptor subfamily 3 group C member 1
Background	Glucocorticoid receptor is a ~85 kDa protein. Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. 1. Vitellius, G. et al. (2016) Human mutation 37, 794-803. PMID: 27120390 2. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846 3. Fadda, A. et al. (2017) Scientific reports 7, 41598. PMID: 28139699 4. Fryer, CJ. et al. (1998) Nature 393, 88-91. PMID: 9590696 5. Cho, H. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, E1540-9. PMID: 25775514
Note	For research use only

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Datasheet

Human NR3C1 Recombinant Protein (N-His).pdf

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Human NR3C1 Recombinant Protein (N-His) (HY450022)

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