Human OTUD7B Recombinant Protein (N-His) (HC193012)

Name: Human OTUD7B Recombinant Protein (N-His)
Brand: abinScience
SKU: HC193012
Price: 211 USD
Availability: InStock

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概要

カタログ番号	HC193012
説明	Recombinant Human OTUD7B Protein, N-His (HC193012) expressed in E. coli, spanning Gln136-Ser438. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	E. coli
アクセッション番号	Q6GQQ9
タンパク質長	Gln136-Ser438
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	36.73 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	Cellular zinc finger anti-NF-kappa-B protein, Cezanne, EC:3.4.19.12, OTU domain-containing protein 7B, OTUD7B, ZA20D1, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne
背景	OTU domain-containing protein 7B is a ~92 kDa protein. Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. 1. Enesa, K. et al. (2008) The Journal of biological chemistry 283, 7036-45. PMID: 18178551 2. Hu, H. et al. (2016) The Journal of experimental medicine 213, 399-414. PMID: 26903241 3. Pareja, F. et al. (2012) Oncogene 31, 4599-608. PMID: 22179831 4. Evans, PC. et al. (2001) The Biochemical journal 357, 617-23. PMID: 11463333 5. Bremm, A. et al. (2010) Nature structural & molecular biology 17, 939-47. PMID: 20622874 6. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 7. Mevissen, TET. et al. (2016) Nature 538, 402-405. PMID: 27732584 8. Evans, PC. et al. (2003) The Journal of biological chemistry 278, 23180-6. PMID: 12682062 9. Wang, B. et al. (2017) Nature 545, 365-369. PMID: 28489822
注意事項	For research use only

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データシート

Human OTUD7B Recombinant Protein (N-His).pdf

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Human OTUD7B Recombinant Protein (N-His) (HC193012)

概要

イメージ

参考文献

データシート

SDS

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