Human PARP14 Recombinant Protein (N-His) (HS727012)

Name: Human PARP14 Recombinant Protein (N-His)
Brand: abinScience
SKU: HS727012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HS727012
Description	Recombinant Human PARP14 Protein, N-His (HS727012) expressed in E. coli, spanning Ala788-Leu1194. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q460N5
Longueur de protéine	Ala788-Leu1194
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	46.25 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	ADP-ribosyltransferase diphtheria toxin-like 8, ARTD8, B aggressive lymphoma protein 2, BAL2, EC:2.4.2.-, KIAA1268, PARP-14, PARP14, Poly [ADP-ribose] polymerase 14, Protein mono-ADP-ribosyltransferase PARP14
Contexte	Protein mono-ADP-ribosyltransferase PARP14 is a ~202 kDa protein. ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703'. Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription. 1. Aguiar, RC. et al. (2005) The Journal of biological chemistry 280, 33756-65. PMID: 16061477 2. Kleine, H. et al. (2008) Molecular cell 32, 57-69. PMID: 18851833 3. Vyas, S. et al. (2014) Nature communications 5, 4426. PMID: 25043379 4. Iwata, H. et al. (2016) Nature communications 7, 12849. PMID: 27796300 5. Begitt, A. et al. (2018) Nature communications 9, 2144. PMID: 29858569
Note	For research use only

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Human PARP14 Recombinant Protein (N-His).pdf

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