Anti-Human PARP14 IP Recombinant Antibody (SAA0213) (HS727013)

Name: Anti-Human PARP14 IP Recombinant Antibody (SAA0213)
Brand: abinScience
SKU: HS727013
Price: 191 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HS727013

Species reactivity

Human

Applications

ELISA, IF, IP

Host species

Mouse

Isotype

IgG1

Clone ID

SAA0213

Clonality

Monoclonal

Target

BAL2, B aggressive lymphoma protein 2, PARP14, Poly [ADP-ribose] polymerase 14, Protein mono-ADP-ribosyltransferase PARP14, PARP-14, ADP-ribosyltransferase diphtheria toxin-like 8, KIAA1268, ARTD8

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q460N5

RRID

Anti-Human PARP14 IP Antibody (SAA0213) (abinScience Cat# HS727013, RRID:AB_3729747)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Protein mono-ADP-ribosyltransferase PARP14 is a ~202 kDa protein. ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703'. Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription.

1. Aguiar, RC. et al. (2005) The Journal of biological chemistry 280, 33756-65. PMID: 16061477

2. Kleine, H. et al. (2008) Molecular cell 32, 57-69. PMID: 18851833

3. Vyas, S. et al. (2014) Nature communications 5, 4426. PMID: 25043379

4. Iwata, H. et al. (2016) Nature communications 7, 12849. PMID: 27796300

5. Begitt, A. et al. (2018) Nature communications 9, 2144. PMID: 29858569

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human PARP14 IP Antibody (SAA0213)

References

Datasheet

Anti-Human PARP14 IP Recombinant Antibody (SAA0213).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human PARP14 IP Recombinant Antibody (SAA0213) (HS727013)

Overview

Images

References

Datasheet

SDS

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