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| カタログ番号 | HD207012 |
|---|---|
| 説明 |
Recombinant Human RAB32 Protein, N-His (HD207012) expressed in E. coli, spanning Met1-Cys225. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q13637 |
| タンパク質長 | Met1-Cys225 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 27.16 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:3.6.5.2, RAB32, Ras-related protein Rab-32 |
| 背景 | Ras-related protein Rab-32 is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. 1. Bao, X. et al. (2002) European journal of biochemistry 269, 259-71. PMID: 11784320 2. Nottingham, RM. et al. (2011) The Journal of biological chemistry 286, 33213-22. PMID: 21808068 3. Alto, NM. et al. (2002) The Journal of cell biology 158, 659-68. PMID: 12186851 4. Seto, S. et al. (2011) Traffic (Copenhagen, Denmark) 12, 407-20. PMID: 21255211 5. Gerondopoulos, A. et al. (2012) Current biology : CB 22, 2135-9. PMID: 23084991 6. Zhu, H. et al. (2023) Science (New York, N.Y.) 382, 1404-1411. PMID: 38127736 |
| 注意事項 | For research use only |
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