Human RICTOR Recombinant Protein (N-His) (HP601022)

Name: Human RICTOR Recombinant Protein (N-His)
Brand: abinScience
SKU: HP601022
Price: 211 USD
Availability: InStock

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概要

カタログ番号	HP601022
説明	Recombinant Human RICTOR Protein, N-His (HP601022) expressed in E. coli, spanning Arg32-Leu254. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	E. coli
アクセッション番号	Q6R327
タンパク質長	Arg32-Leu254
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	27.56 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	AVO3 homolog, KIAA1999, RICTOR, Rapamycin-insensitive companion of mTOR, hAVO3
背景	Rapamycin-insensitive companion of mTOR is a ~192 kDa protein. Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. In contrast to mTORC1, mTORC2 is nutrient-insensitive. Within the mTORC2 complex, RICTOR probably acts as a molecular adapter. RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2. 1. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 15268862 2. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470 3. Dibble, CC. et al. (2009) Molecular and cellular biology 29, 5657-70. PMID: 19720745 4. Julien, LA. et al. (2010) Molecular and cellular biology 30, 908-21. PMID: 19995915 5. Chen, CH. et al. (2011) Science signaling 4, ra10. PMID: 21343617 6. Scaiola, A. et al. (2020) Science advances 6. PMID: 33158864 7. Zhuang, L. et al. (2022) Cell biology international 46, 1693-1703. PMID: 35904232 8. Yu, Z. et al. (2022) The Journal of biological chemistry 298, 102288. PMID: 35926713 9. Treins, C. et al. (2010) Oncogene 29, 1003-16. PMID: 19935711 10. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 15467718
注意事項	For research use only

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データシート

Human RICTOR Recombinant Protein (N-His).pdf

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Human RICTOR Recombinant Protein (N-His) (HP601022)

概要

イメージ

参考文献

データシート

SDS

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