Anti-Human RICTOR Polyclonal Antibody (HP601014)

Name: Anti-Human RICTOR Polyclonal Antibody
Brand: abinScience
SKU: HP601014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP601014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human RICTOR (Arg32-Glu140).

Target

KIAA1999, Rapamycin-insensitive companion of mTOR, hAVO3, RICTOR, AVO3 homolog

Purification

Purified by antigen affinity column.

Accession

Q6R327

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Rapamycin-insensitive companion of mTOR (RICTOR) is a ~192 kDa protein. Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. In contrast to mTORC1, mTORC2 is nutrient-insensitive. Within the mTORC2 complex, RICTOR probably acts as a molecular adapter. RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2.

1. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 15268862

2. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470

3. Dibble, CC. et al. (2009) Molecular and cellular biology 29, 5657-70. PMID: 19720745

4. Julien, LA. et al. (2010) Molecular and cellular biology 30, 908-21. PMID: 19995915

5. Chen, CH. et al. (2011) Science signaling 4, ra10. PMID: 21343617

6. Scaiola, A. et al. (2020) Science advances 6. PMID: 33158864

7. Zhuang, L. et al. (2022) Cell biology international 46, 1693-1703. PMID: 35904232

8. Yu, Z. et al. (2022) The Journal of biological chemistry 298, 102288. PMID: 35926713

9. Treins, C. et al. (2010) Oncogene 29, 1003-16. PMID: 19935711

10. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 15467718

Note

For research use only.

Images

References

Datasheet

Anti-Human RICTOR Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human RICTOR Polyclonal Antibody (HP601014)

Overview

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