Human SETD1A Recombinant Protein (N-His) (HC879012)

Name: Human SETD1A Recombinant Protein (N-His)
Brand: abinScience
SKU: HC879012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HC879012
Description	Recombinant Human SETD1A Protein, N-His (HC879012) expressed in E. coli, spanning Val1524-Ser1670. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	O15047
Longueur de protéine	Val1524-Ser1670
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	19.25 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	EC:2.1.1.364, Histone-lysine N-methyltransferase SETD1A, KIAA0339, KMT2F, Lysine N-methyltransferase 2F, SET domain-containing protein 1A, SET1, SET1A, SETD1A, Set1/Ash2 histone methyltransferase complex subunit SET1, hSET1A
Contexte	Histone-lysine N-methyltransferase SETD1A is a ~186 kDa protein. Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. 1. Wysocka, J. et al. (2003) Genes & development 17, 896-911. PMID: 12670868 2. Shinsky, SA. et al. (2015) The Journal of biological chemistry 290, 6361-75. PMID: 25561738 3. Higgs, MR. et al. (2018) Molecular cell 71, 25-41.e6. PMID: 29937342 4. Yu, X. et al. (2019) Neuroscience bulletin 35, 1045-1057. PMID: 31197650 5. Kummeling, J. et al. (2021) Molecular psychiatry 26, 2013-2024. PMID: 32346159 6. Amin, HM. et al. (2023) International journal of molecular sciences 24. PMID: 38003223
Note	For research use only

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Human SETD1A Recombinant Protein (N-His).pdf

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