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Anti-Human SETD1A Polyclonal Antibody (HC879014)

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Overview
Catalog No.HC879014
Description
Anti-Human SETD1A Polyclonal Antibody (HC879014) is a rabbit polyclonal antibody detecting SETD1A. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human SETD1A (Val1524-Ser1670).
Target EC:2.1.1.364, Histone-lysine N-methyltransferase SETD1A, KIAA0339, KMT2F, Lysine N-methyltransferase 2F, SET domain-containing protein 1A, SET1, SET1A, SETD1A, Set1/Ash2 histone methyltransferase complex subunit SET1, hSET1A
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O15047
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Histone-lysine N-methyltransferase SETD1A is a ~186 kDa protein. Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation.

1. Wysocka, J. et al. (2003) Genes & development 17, 896-911. PMID: 12670868
2. Shinsky, SA. et al. (2015) The Journal of biological chemistry 290, 6361-75. PMID: 25561738
3. Higgs, MR. et al. (2018) Molecular cell 71, 25-41.e6. PMID: 29937342
4. Yu, X. et al. (2019) Neuroscience bulletin 35, 1045-1057. PMID: 31197650
5. Kummeling, J. et al. (2021) Molecular psychiatry 26, 2013-2024. PMID: 32346159
6. Amin, HM. et al. (2023) International journal of molecular sciences 24. PMID: 38003223
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human SETD1A Polyclonal Antibody

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