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| カタログ番号 | HB272012 |
|---|---|
| 説明 |
Recombinant Human SLC5A1 Protein, N-His (HB272012) expressed in E. coli. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P13866 |
| タンパク質長 | Asp230-Pro277&Ser335-Gly380&Arg564-Thr643 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 22.70 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | High affinity sodium-glucose cotransporter, NAGT, Na(+)/glucose cotransporter 1, SGLT1, SLC5A1, Sodium/glucose cotransporter 1, Solute carrier family 5 member 1 |
| 背景 | Sodium/glucose cotransporter 1 is a ~73 kDa protein. Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. 1. Hummel, CS. et al. (2011) American journal of physiology. Cell physiology 300, C14-21. PMID: 20980548 2. Han, L. et al. (2022) Nature 601, 274-279. PMID: 34880492 3. Kamitori, K. et al. (2022) Journal of molecular biology 434, 167464. PMID: 35077764 4. Martín, MG. et al. (1996) Nature genetics 12, 216-20. PMID: 8563765 5. Cui, W. et al. (2023) Nature communications 14, 2920. PMID: 37217492 6. Salker, MS. et al. (2017) Scientific reports 7, 12612. PMID: 28974690 |
| 注意事項 | For research use only |
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