Anti-Human SLC5A1 Polyclonal Antibody (HB272014)

Name: Anti-Human SLC5A1 Polyclonal Antibody
Brand: abinScience
SKU: HB272014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HB272014

Description

Anti-Human SLC5A1 Polyclonal Antibody (HB272014) is a rabbit polyclonal antibody detecting SLC5A1. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SLC5A1 (Asp230-Pro277&Ser335-Gly380&Arg564-Thr643).

Target

High affinity sodium-glucose cotransporter, NAGT, Na(+)/glucose cotransporter 1, SGLT1, SLC5A1, Sodium/glucose cotransporter 1, Solute carrier family 5 member 1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P13866

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Sodium/glucose cotransporter 1 (SLC5A1) is a ~73 kDa protein. Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis.

1. Hummel, CS. et al. (2011) American journal of physiology. Cell physiology 300, C14-21. PMID: 20980548

2. Han, L. et al. (2022) Nature 601, 274-279. PMID: 34880492

3. Kamitori, K. et al. (2022) Journal of molecular biology 434, 167464. PMID: 35077764

4. Martín, MG. et al. (1996) Nature genetics 12, 216-20. PMID: 8563765

5. Cui, W. et al. (2023) Nature communications 14, 2920. PMID: 37217492

6. Salker, MS. et al. (2017) Scientific reports 7, 12612. PMID: 28974690

Note

For research use only

Images

References

Datasheet

Anti-Human SLC5A1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SLC5A1 Polyclonal Antibody (HB272014)

Overview

Images

References

Datasheet

SDS

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