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| カタログ番号 | HX906022 |
|---|---|
| 説明 |
Recombinant Human SNRPD1 Protein, N-GST & C-His (HX906022) expressed in E. coli, spanning Lys2-Val87. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P62314 |
| タンパク質長 | Lys2-Val87 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 37.89 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | SNRPD1, Sm-D autoantigen, Sm-D1, Small nuclear ribonucleoprotein Sm D1, snRNP core protein D1 |
| 背景 | Small nuclear ribonucleoprotein Sm D1 is a ~13 kDa protein. Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. 1. Jurica, MS. et al. (2002) RNA (New York, N.Y.) 8, 426-39. PMID: 11991638 2. Chari, A. et al. (2008) Cell 135, 497-509. PMID: 18984161 3. Pomeranz Krummel, DA. et al. (2009) Nature 458, 475-80. PMID: 19325628 4. Grimm, C. et al. (2013) Molecular cell 49, 692-703. PMID: 23333303 5. Kondo, Y. et al. (2015) eLife 4. PMID: 25555158 6. Agafonov, DE. et al. (2016) Science (New York, N.Y.) 351, 1416-20. PMID: 26912367 7. Bertram, K. et al. (2017) Nature 542, 318-323. PMID: 28076346 8. Zhang, X. et al. (2017) Cell 169, 918-929.e14. PMID: 28502770 9. Bertram, K. et al. (2017) Cell 170, 701-713.e11. PMID: 28781166 10. Zhang, Z. et al. (2020) Nature 583, 310-313. PMID: 32494006 |
| 注意事項 | For research use only |
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