Human THOC5 Recombinant Protein (N-His) (HD208012)

Name: Human THOC5 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD208012
Price: 211 USD
Availability: InStock

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Número de catálogo	HD208012
Descripción	Recombinant Human THOC5 Protein, N-His (HD208012) expressed in E. coli, spanning His263-Arg683. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q13769
Longitud de proteína	His263-Arg683
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	49.86 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	C22orf19, Functional spliceosome-associated protein 79, KIAA0983, NF2/meningioma region protein pK1.3, PP39.2, Placental protein 39.2, THO complex subunit 5, THOC5, fSAP79, hTREX90
Fondo	THO complex subunit 5 is a ~78 kDa protein. Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. 1. Guo, S. et al. (2005) Cancer research 65, 3011-6. PMID: 15833825 2. Masuda, S. et al. (2005) Genes & development 19, 1512-7. PMID: 15998806 3. Cheng, H. et al. (2006) Cell 127, 1389-400. PMID: 17190602 4. Pühringer, T. et al. (2020) eLife 9. PMID: 33191911 5. Boyne, JR. et al. (2008) PLoS pathogens 4, e1000194. PMID: 18974867 6. Katahira, J. et al. (2013) Nucleic acids research 41, 7060-72. PMID: 23685434
Nota	For research use only

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Datasheet

Human THOC5 Recombinant Protein (N-His).pdf

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