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Anti-Human THOC5 Polyclonal Antibody (HD208014)

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Overview
Catalog No.HD208014
Description
Anti-Human THOC5 Polyclonal Antibody (HD208014) is a rabbit polyclonal antibody detecting THOC5. Suitable for Rat, Mouse, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human THOC5 (His263-Arg683).
Target C22orf19, Functional spliceosome-associated protein 79, KIAA0983, NF2/meningioma region protein pK1.3, PP39.2, Placental protein 39.2, THO complex subunit 5, THOC5, fSAP79, hTREX90
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q13769
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

THO complex subunit 5 (THOC5) is a ~78 kDa protein. Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability.

1. Guo, S. et al. (2005) Cancer research 65, 3011-6. PMID: 15833825
2. Masuda, S. et al. (2005) Genes & development 19, 1512-7. PMID: 15998806
3. Cheng, H. et al. (2006) Cell 127, 1389-400. PMID: 17190602
4. Pühringer, T. et al. (2020) eLife 9. PMID: 33191911
5. Boyne, JR. et al. (2008) PLoS pathogens 4, e1000194. PMID: 18974867
6. Katahira, J. et al. (2013) Nucleic acids research 41, 7060-72. PMID: 23685434
Note For research use only
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Datasheet
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Formula
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Anti-Human THOC5 Polyclonal Antibody

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