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| カタログ番号 | HW693022 |
|---|---|
| 説明 |
Recombinant Human TMED10 Protein, N-His (HW693022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P49755 |
| タンパク質長 | Ile32-Arg185 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 21 kDa transmembrane-trafficking protein, Protein TMED10, S31I125, S31III125, TMED10, TMP21, Tmp-21-I, Transmembrane emp24 domain-containing protein 10, Transmembrane protein Tmp21, p23, p24 family protein delta-1, p24delta, p24delta1 |
| 背景 | Transmembrane emp24 domain-containing protein 10 is a ~24 kDa protein. Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi. The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes. Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side. Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles. In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. 1. Bremser, M. et al. (1999) Cell 96, 495-506. PMID: 10052452 2. Gommel, DU. et al. (2001) The EMBO journal 20, 6751-60. PMID: 11726511 3. Chen, F. et al. (2006) Nature 440, 1208-12. PMID: 16641999 4. Vetrivel, KS. et al. (2007) Molecular neurodegeneration 2, 4. PMID: 17288597 5. Luo, R. et al. (2009) Cellular signalling 21, 1169-79. PMID: 19296914 6. Bonnon, C. et al. (2010) Journal of cell science 123, 1705-15. PMID: 20427317 7. Luo, W. et al. (2011) Journal of neurochemistry 117, 71-81. PMID: 21219331 8. Nagae, M. et al. (2016) Journal of molecular biology 428, 4087-4099. PMID: 27569046 |
| 注意事項 | For research use only |
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