Anti-Human TMED10 Polyclonal Antibody (HW693014)

Name: Anti-Human TMED10 Polyclonal Antibody
Brand: abinScience
SKU: HW693014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HW693014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TMED10 (Ile32-Lys133).

Target

S31I125, Tmp-21-I, Transmembrane protein Tmp21, Transmembrane emp24 domain-containing protein 10, TMP21, TMED10, 21 kDa transmembrane-trafficking protein, p23, S31III125, Protein TMED10, p24delta1, p24 family protein delta-1, p24delta

Purification

Purified by antigen affinity column.

Accession

P49755

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Transmembrane emp24 domain-containing protein 10 (TMED10) is a ~24 kDa protein. Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi. The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes. Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side. Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles. In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER.

1. Bremser, M. et al. (1999) Cell 96, 495-506. PMID: 10052452

2. Gommel, DU. et al. (2001) The EMBO journal 20, 6751-60. PMID: 11726511

3. Chen, F. et al. (2006) Nature 440, 1208-12. PMID: 16641999

4. Vetrivel, KS. et al. (2007) Molecular neurodegeneration 2, 4. PMID: 17288597

5. Luo, R. et al. (2009) Cellular signalling 21, 1169-79. PMID: 19296914

6. Bonnon, C. et al. (2010) Journal of cell science 123, 1705-15. PMID: 20427317

7. Luo, W. et al. (2011) Journal of neurochemistry 117, 71-81. PMID: 21219331

8. Nagae, M. et al. (2016) Journal of molecular biology 428, 4087-4099. PMID: 27569046

Note

For research use only.

Images

References

Datasheet

Anti-Human TMED10 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human TMED10 Polyclonal Antibody (HW693014)

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