

| Каталожный номер | HD404012 |
|---|---|
| Описание |
Recombinant Human TSPAN14 Protein, N-His (HD404012) expressed in E. coli, spanning Leu114-Asn232. Purity: >90% by SDS-PAGE.
Highlights
|
| Система экспрессии | E. coli |
| Номер доступа | Q8NG11 |
| Длина белка | Leu114-Asn232 |
| Применения | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Виды | Homo sapiens (Human) |
| Характер | Recombinant |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Чистота | >90% as determined by SDS-PAGE. |
| Прогнозируемая молекулярная масса | 16.12 kDa |
| Форма | Lyophilized |
| Буфер хранения | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Реконституция | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Доставка | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Альтернативные названия | DC-TM4F2, TM4SF14, TSPAN14, Tetraspanin-14, Transmembrane 4 superfamily member 14, Tspan-14 |
| Фон | Tetraspanin-14 is a ~30 kDa protein. Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Negatively regulates ADAM10-mediated cleavage of GP6. Promotes ADAM10-mediated cleavage of CDH5. 1. Haining, EJ. et al. (2012) The Journal of biological chemistry 287, 39753-65. PMID: 23035126 2. Noy, PJ. et al. (2016) The Journal of biological chemistry 291, 3145-57. PMID: 26668317 3. Jouannet, S. et al. (2016) Cellular and molecular life sciences : CMLS 73, 1895-915. PMID: 26686862 4. Lipper, CH. et al. (2023) Cell 186, 3632-3641.e10. PMID: 37516108 |
| Примечание | For research use only |
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