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| カタログ番号 | HC178012 |
|---|---|
| 説明 |
Recombinant Human USP5 Protein, N-His (HC178012) expressed in E. coli, spanning Lys163-Lys291. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P45974 |
| タンパク質長 | Lys163-Lys291 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 16.87 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Deubiquitinating enzyme 5, EC:3.4.19.12, ISOT, Isopeptidase T, USP5, Ubiquitin carboxyl-terminal hydrolase 5, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5 |
| 背景 | Ubiquitin carboxyl-terminal hydrolase 5 is a ~95 kDa protein. Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter. Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains. Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein. 1. Chen, Y. et al. (2016) The EMBO journal 35, 668-84. PMID: 26912724 2. Xie, X. et al. (2018) Journal of cell science 131. PMID: 29567855 3. Shi, S. et al. (2023) Hepatology communications 7. PMID: 37534934 4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329 5. Pai, YL. et al. (2023) Cell death & disease 14, 540. PMID: 37607937 6. Qiao, Z. et al. (2025) PLoS pathogens 21, e1012843. PMID: 39761299 7. Mao, C. et al. (2024) The Journal of biological chemistry 300, 107592. PMID: 39032648 8. Shao, N. et al. (2025) Nature communications 16, 1313. PMID: 39900921 |
| 注意事項 | For research use only |
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