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Anti-Human USP5 Polyclonal Antibody (HC178014)

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Overview
Catalog No.HC178014
Description
Anti-Human USP5 Polyclonal Antibody (HC178014) is a rabbit polyclonal antibody detecting USP5. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human USP5 (Lys163-Lys291).
Target Deubiquitinating enzyme 5, EC:3.4.19.12, ISOT, Isopeptidase T, USP5, Ubiquitin carboxyl-terminal hydrolase 5, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P45974
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Ubiquitin carboxyl-terminal hydrolase 5 (USP5) is a ~95 kDa protein. Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter. Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains. Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.

1. Chen, Y. et al. (2016) The EMBO journal 35, 668-84. PMID: 26912724
2. Xie, X. et al. (2018) Journal of cell science 131. PMID: 29567855
3. Shi, S. et al. (2023) Hepatology communications 7. PMID: 37534934
4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329
5. Pai, YL. et al. (2023) Cell death & disease 14, 540. PMID: 37607937
6. Qiao, Z. et al. (2025) PLoS pathogens 21, e1012843. PMID: 39761299
7. Mao, C. et al. (2024) The Journal of biological chemistry 300, 107592. PMID: 39032648
8. Shao, N. et al. (2025) Nature communications 16, 1313. PMID: 39900921
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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V₁ (Stock Vol.)
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C₂ (Working Conc.)
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Anti-Human USP5 Polyclonal Antibody

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